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pentobarbital will reduce the extent or impact of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or influence of carbamazepine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.Anticoagulants: Phenobarbital lowers the plasma levels of dicumarol (name Earlier